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Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique
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Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique

Published on: December 15, 2023

Corrigendum to: Neuroprotective Mechanisms of Oxygen and Ethanol: A Potential Combination Therapy in Stroke

Sweena Parmar1, Shannon Moore-Langston1, Vance Fredrickson1

  • 1Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, Michigan, 48201, USA.

Current Medicinal Chemistry
|July 1, 2026
PubMed

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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
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