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Related Concept Videos

Decreased Body Temperature01:29

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...

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Related Experiment Video

Updated: Jul 2, 2026

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods
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Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Published on: October 10, 2025

Cold-Driven Thermoelectric Patch for Postoperative Tumor Control.

Linghui Lyu1, Jiajun Zhou1, Yuyan Zou1

  • 1Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, Hunan, China.

ACS Nano
|July 1, 2026
PubMed
Summary
This summary is machine-generated.

This study presents a wearable cold-catalytic patch that activates the immune system and enhances tissue repair after surgery. The patch effectively suppresses residual tumors and improves wound healing, offering a new approach to postoperative cancer therapy.

Keywords:
antitumorcold catalysishydrogelthermoelectrocatalysiswound healing

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Immunology

Background:

  • Postoperative tumor management is challenged by residual tumor cells, immune suppression, and poor wound healing.
  • Surgical removal of tumors eliminates antigen sources, increasing vulnerability to recurrence and metastasis.
  • Current strategies lack integrated approaches for simultaneous immune activation and tissue repair.

Purpose of the Study:

  • To develop a flexible wearable cold-catalytic patch for synergistic immune activation and enhanced tissue repair.
  • To investigate the patch's ability to address challenges in postoperative tumor management.
  • To provide a broadly applicable paradigm for next-generation postoperative tumor therapy.

Main Methods:

  • Fabrication of a wearable patch integrating thermoelectric nanorods, enzymatic components, and a zwitterionic hydrogel.
  • Utilizing localized cold stimulation to trigger thermoelectrocatalytic generation of reactive oxygen and nitrogen species.
  • Evaluating the patch's effects on immune cell infiltration, antigen presentation, cytokine secretion, and wound healing in vivo.

Main Results:

  • The patch successfully generated reactive oxygen and nitrogen species, promoting antigen presentation and immune cell infiltration.
  • Thermoelectrical cues and nitric oxide (NO) signaling accelerated fibroblast migration, angiogenesis, and extracellular matrix remodeling.
  • In vivo studies confirmed suppression of residual tumor proliferation and distant metastasis, alongside significantly improved wound healing quality.

Conclusions:

  • The developed thermoelectrocatalytic patch offers a unified strategy for activating immune responses and promoting tissue repair.
  • This approach effectively combats residual tumors and enhances postoperative recovery.
  • The wearable patch represents a promising paradigm for advanced postoperative cancer treatment.