Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adherence to Red Reflex and Vision Screening Recommendations: A Deep Dive into Primary Care Implementation Gaps.

medRxiv : the preprint server for health sciences·2026
Same author

Comparison of postocclusion surge between venturi and peristaltic phacoemulsification pump type.

Journal of cataract and refractive surgery·2026
Same author

Comparison of Postocclusion Pressure Surge Between Pressure Sensing and Traditional Phacoemulsification Handpieces.

Journal of ophthalmology·2025
Same author

Energy Output Variability Among Phacoemulsification Tips Using Calorimetry.

Medical devices (Auckland, N.Z.)·2025
Same author

Comparison of Ultrasound Energy Delivered to the Anterior Segment Across Different Phacoemulsification Surgical Platforms.

Medical devices (Auckland, N.Z.)·2025
Same author

Discrepancies in CDE and Measured Phaco Tip Energy: Comparison of Energy Produced in Longitudinal and Torsional Ultrasound Using Calorimetry.

Medical devices (Auckland, N.Z.)·2024
Same journal

Patient-Reported Outcomes and Wound-Related Quality of Life in Adults with Diabetic Foot Ulcers Treated with Silicone Superabsorbent Polymer Dressings: Exploratory Results from a Prospective Multicenter Nonrandomized Cohort Study.

Medical devices (Auckland, N.Z.)·2026
Same journal

Patient-Centric Design of the Lonapegsomatropin Auto-Injector for Growth Hormone Deficiency: Usability Validation of Safe and Effective Use.

Medical devices (Auckland, N.Z.)·2026
Same journal

Real-World Performance of the Veriset Hemostatic Patch: A Multicenter Study of Adjunctive Hemostasis.

Medical devices (Auckland, N.Z.)·2026
Same journal

Efficacy, Safety and Oncological Outcomes of Minimally Invasive Approaches (EMR, ESD and TAMIS) for Early Rectal Tumors: A Systematic Review and Meta-Analysis.

Medical devices (Auckland, N.Z.)·2026
Same journal

Preclinical Feasibility of the ELANA End-to-End Anastomotic Technique in a Porcine Pilot Study.

Medical devices (Auckland, N.Z.)·2026
Same journal

AI Characterisation of Discordance Profiles Between Stress Electrocardiogram and Myocardial Tomoscintigraphy Using Random Forest XGBoost and SHAP.

Medical devices (Auckland, N.Z.)·2026
See all related articles

Related Experiment Video

Updated: Jul 2, 2026

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
09:03

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Published on: June 20, 2015

Comparing Post-Occlusion Surge at Decreasing Intraocular Pressures with Pressure Sensing Handpiece.

Jessie A Montgomery1,2, Coby Soule1,2, Nathan Sherbotie1,2

  • 1Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah, Salt Lake City, UT, USA.

Medical Devices (Auckland, N.Z.)
|July 1, 2026
PubMed
Summary
This summary is machine-generated.

The Active Sentry handpiece shows increased surge risk at 30 mmHg intraocular pressure (IOP), but not at 50 mmHg compared to 70 mmHg. This study evaluated post-occlusion surge pressure with the Active Sentry handpiece.

Keywords:
cataractcomplicationsintraocular pressuresurgeultrasound energy

More Related Videos

Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance
07:27

Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance

Published on: August 25, 2021

Related Experiment Videos

Last Updated: Jul 2, 2026

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
09:03

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Published on: June 20, 2015

Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance
07:27

Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance

Published on: August 25, 2021

Area of Science:

  • Ophthalmology
  • Surgical Technology

Background:

  • Phacoemulsification is a common cataract surgery technique.
  • Intraocular pressure (IOP) management is critical during cataract surgery.
  • Post-occlusion surge can occur during phacoemulsification, potentially leading to complications.

Purpose of the Study:

  • To compare post-occlusion surge pressure at various intraocular pressures (IOPs) using the Active Sentry handpiece.
  • To evaluate the safety profile of the Active Sentry handpiece at different IOP settings.

Main Methods:

  • An in vitro study using the Alcon Centurion platform and Active Sentry handpiece.
  • Simulated phacoemulsification tip occlusion and release at IOPs of 30, 50, and 70 mmHg.
  • Continuous monitoring of pressure changes using an electric pressure sensor.

Main Results:

  • At 70 mmHg IOP, surge magnitude was 5.76 mmHg (duration 0.45s). At 50 mmHg IOP, surge magnitude was 5.76 mmHg (duration 0.52s).
  • At 30 mmHg IOP, surge magnitude increased to 10.46 mmHg (duration 1.27s).
  • Statistically significant differences in surge magnitude and duration were observed between 30 mmHg and both 50 and 70 mmHg IOPs (P < 0.05).

Conclusions:

  • The Active Sentry handpiece does not increase surge risk when IOP is decreased from 70 to 50 mmHg.
  • A decrease in operative IOP to 30 mmHg with the Active Sentry handpiece is associated with increased surge risk.
  • The Active Sentry handpiece appears safe at 50 mmHg IOP regarding surge risk compared to 70 mmHg IOP.