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Published on: February 28, 2025
Exosome-Biomaterial Platforms for Diabetic Skin Infections: Microenvironment Remodeling, Responsive Delivery, and
Jian Xiao1, Zekun He2, Yitian Bu1
1The First People's Hospital of Jiashan, Jiashan Hospital Affiliated to Jiaxing University, Jiaxing, 314100, People's Republic of China.
International Journal of Nanomedicine
|July 1, 2026
Summary
Exosome-biomaterial systems show promise for treating diabetic foot ulcers by delivering therapeutic exosomes effectively. These advanced systems combat infection and promote healing in preclinical models, though clinical evidence is still needed.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Wound Healing
Background:
- Diabetic foot ulcers (DFU) present a complex challenge due to a hostile microenvironment hindering conventional treatments.
- Exosomes offer therapeutic potential for DFU by regulating key healing processes, but direct administration faces limitations.
Purpose of the Study:
- To review recent advancements in exosome-biomaterial systems for treating diabetic skin infections.
- To highlight the design, mechanisms, and translational challenges of these innovative therapeutic platforms.
Main Methods:
- Summarized recent research on exosome-biomaterial systems for diabetic wound repair.
- Focused on delivery strategies, microenvironment-responsive release, and anti-infective/regenerative mechanisms.
- Compared various biomaterial platforms and discussed clinical translation hurdles.
Main Results:
- Exosome-biomaterial systems demonstrate potential in preclinical models for improving wound closure, vascularization, and infection control.
- These systems can protect exosome bioactivity, enhance local retention, and enable controlled release.
- Biomaterials can be engineered to address pathological barriers like biofilms, oxidative stress, and hypoxia.
Conclusions:
- Exosome-biomaterial systems represent a promising strategy for managing complex diabetic skin infections.
- Further research is required to address standardization, manufacturing, and clinical validation for effective translation.
- High-quality clinical data is essential to confirm the efficacy and safety of these systems in patients.
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01:31Diabetic Foot Ulcer
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