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Related Experiment Video

Updated: Jul 3, 2026

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets
06:12

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Published on: March 17, 2023

Highly sensitive hydrogel surface-enhanced Raman scattering chips with multi-analyte detection ability.

Jiadan Zhang1, Rongjing Hu1, Jingwen Zhang1

  • 1MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350116, China.

Talanta
|July 1, 2026
PubMed
Summary
This summary is machine-generated.

Highly sensitive hydrogel SERS chips were developed using aggregated silver nanocages for multi-analyte detection. These robust chips offer excellent stability and uniformity for real-world sensing applications.

Keywords:
Aggregated silver nanocagesHighly sensitiveHydrogelMulti-analyte detection abilitySurface-enhanced Raman spectroscopy

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Area of Science:

  • Materials Science
  • Analytical Chemistry
  • Nanotechnology

Background:

  • Surface-enhanced Raman spectroscopy (SERS) is a sensitive analytical technique.
  • Developing SERS substrates with high sensitivity, uniformity, stability, and multi-analyte capability is challenging.

Purpose of the Study:

  • To fabricate highly sensitive hydrogel SERS chips for multi-analyte detection.
  • To embed aggregated silver nanocages (a-AgNCs) into a polyvinyl alcohol hydrogel matrix.

Main Methods:

  • Physical cross-linking method to embed a-AgNCs into a polyvinyl alcohol hydrogel.
  • Utilized the localized surface plasmon resonance (LSPR) of a-AgNCs (peak at 495 nm) with a 532 nm laser.
  • Incorporated photo-induced charge transfer for chemical enhancement.

Main Results:

  • Achieved an ultrahigh enhancement factor of 2.12 × 10^10.
  • Demonstrated exceptional signal uniformity (RSD = 1.22%) and inter-batch reproducibility (RSD = 4.84%).
  • Exhibited long-term stability (6 weeks at 4°C, >16 weeks at -20°C) and multi-analyte detection of antibiotics and pesticides at trace levels.
  • Validated practical application by detecting triazophos in food samples (LOD = 2.1 ng/mL, recovery = 91-101%).

Conclusions:

  • Hydrogel SERS chips offer a robust and versatile platform for high-sensitivity, multi-analyte sensing.
  • The developed substrate is suitable for real-world applications requiring sensitive and reliable detection.