[Transition in Differences of Sex Development (DSD): From Human Being to Person]

Transitioning adolescents with Differences of Sex Development (DSD) into adult healthcare requires coordinated planning due to complex medical, psychosocial, and ethical considerations. Many DSD conditions are rare and insufficiently known in adult medicine, highlighting the need for a structured transition pathway.This article summarizes recommendations derived from clinical guidelines, the Berlin Transition Program, and practical clinical experience. Typical case scenarios (e.g., hypospadias, congenital adrenal hyperplasia (CAH), complete androgen insensitivity syndrome (CAIS), gonadal dysgenesis) are used to illustrate key challenges, therapeutic objectives, and competencies needed for effective transitional care.Findings demonstrate that successful transition depends on clear communication, interdisciplinary collaboration, continuity of care, and the promotion of patient autonomy. Key aspects include the management of hormonal issues, evaluation of structural genital variations, tumor risk assessment, and psychosocial support. Common barriers include limited acceptance of the diagnosis, lack of structural resources, and insufficient expertise within adult healthcare services.A personalized transition plan-supported by medical summaries, imaging reports, and structured patient education-enhances the quality of care and fosters empowerment and participation. The transition process also provides opportunities to reflect on earlier treatment decisions, support parents, and broaden clinical perspectives on identity, gender, and sexuality.