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Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases
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Modifying disease registries to address the evolving field in rare diseases: the iSMAc/ITASMAc experience in spinal

Giorgia Coratti1,2, Chiara Bravetti1, Gianpaolo Cicala1,2

  • 1Centro Clinico Nemo, U.O.C. Neuropsichiatria Infantile, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Frontiers in Neurology
|July 2, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
disease registrylongitudinal dataneuromuscular disordersreal-world dataspinal muscular atrophy

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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
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