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Related Concept Videos

The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

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Related Experiment Video

Updated: Jul 3, 2026

Establishment of a Murine Pulp Exposure Model with a Novel Mouth-Gag for Pulpitis Research
05:16

Establishment of a Murine Pulp Exposure Model with a Novel Mouth-Gag for Pulpitis Research

Published on: October 27, 2023

Decoding signaling crosstalk in pulpitis: pathogenesis and precision therapeutics.

Zhaohui Jia1, Zongzong Sun2, Hairui Zhou3

  • 1The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, Henan, China.

Frontiers in Cell and Developmental Biology
|July 2, 2026
PubMed
Summary
This summary is machine-generated.

Irreversible pulpitis involves severe inflammation and cell death. New therapies target molecular pathways with phytochemicals and biomaterials to promote healing and vital pulp therapy.

Keywords:
pulpitisresearch progressresponsive biomaterialssignaling crosstalkvital pulp therapy

More Related Videos

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
07:07

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

Related Experiment Videos

Last Updated: Jul 3, 2026

Establishment of a Murine Pulp Exposure Model with a Novel Mouth-Gag for Pulpitis Research
05:16

Establishment of a Murine Pulp Exposure Model with a Novel Mouth-Gag for Pulpitis Research

Published on: October 27, 2023

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
07:07

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

Area of Science:

  • Biomaterials Science
  • Molecular Biology
  • Dental Research

Background:

  • Irreversible pulpitis involves severe inflammation in the dentin chamber, leading to pulpal necrosis.
  • Key molecular pathways like TLR/NF-κB, MAPK, and NLRP3 inflammasome drive inflammation and cell death.
  • Counteracting pathways such as Wnt/β-catenin and TGF-β/Smad are suppressed by the inflammatory environment.

Purpose of the Study:

  • To review emerging therapeutic strategies for irreversible pulpitis.
  • To explore molecular interventions targeting inflammatory and regenerative pathways.
  • To discuss advanced biomaterials for pulp tissue engineering.

Main Methods:

  • Literature review synthesizing current research on molecular pathways in pulpitis.
  • Analysis of therapeutic potential of phytochemicals, epigenetic regulators, and pro-resolving mediators (e.g., Resolvin E1).
  • Discussion of microenvironment-responsive biomaterials for dynamic adaptation to pulpal conditions.

Main Results:

  • Targeted interventions can attenuate NF-κB inflammation and enhance Wnt/TGF-β regeneration.
  • Resolvin E1 shows promise in modulating inflammatory and regenerative signaling.
  • Next-generation biomaterials are being developed to address hypoxia and oxidative stress.

Conclusions:

  • Understanding molecular signaling is crucial for developing objective diagnostics and precision therapeutics.
  • Pharmacological and biomaterial-based approaches offer promising strategies for vital pulp therapy.
  • Future research focuses on integrating molecular insights for predictable regenerative outcomes.