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Highlights From the Recent AASLD Guidance on MASLD/MASH in Children

Stavra A Xanthakos1

  • 1Director, Steatohepatitis Center Professor of Pediatrics, Attending Physician Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Department of Pediatrics, University of Cincinnati College of Medicine Cincinnati, Ohio.

Gastroenterology & Hepatology
|July 2, 2026
PubMed
Abstract

No abstract available in PubMed .

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Electron Transport Chain: Complex I and II01:46

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The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...

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