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Autoantibody-mediated pain in long COVID: evidence from multiple lines

Charles Nicaise1, Pierre Bulpa2, Marc Jamoulle3

  • 1URPhyM, NARILIS, Université de Namur, Namur, Belgium.

Frontiers in Immunology
|July 2, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
allodynia and hyperalgesiaautoantibodylong Covidpainpost-acute sequela of COVID-19 (PASC)preclinical (in vivo) studies

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

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