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Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

Systemic Inflammatory Indices Predict Survival and Limb Outcomes after Revascularization for Chronic Limb-Threatening

Franco Imbrognio1, Ignacio Pepe1, Alfredo Verastegui2

  • 1Saavedra Campus, Instituto Universitario CEMIC, Buenos Aires, Argentina.

Journal of Vascular Research
|July 2, 2026
PubMed

Insights

The Systemic Immune-Inflammation Index (SII) can predict survival in chronic limb ischemia patients after revascularization. Lower SII levels correlate with better long-term survival, aiding risk assessment for these high-risk patients.

Area of Science:

  • Vascular Surgery
  • Cardiology
  • Inflammation Biomarkers

Background:

  • Chronic limb-threatening ischemia (CLTI) has high mortality and limited risk stratification tools post-revascularization.
  • Systemic Immune-Inflammation Index (SII) and Systemic Inflammatory Response Index (SIRI) are emerging prognostic markers.

Purpose of the Study:

  • To evaluate the predictive value of SII and SIRI in CLTI patients undergoing revascularization.
  • To assess the association of these indices with survival and adverse events.

Main Methods:

  • Retrospective single-center cohort study of 122 CLTI patients (endovascular angioplasty or surgical bypass).
  • Pre-procedural calculation of SII and SIRI from blood counts.
  • Analysis of overall survival, MACE/MALE, and amputation using Kaplan-Meier and Cox regression.

Main Results:

  • Surgical bypass showed longer survival than angioplasty (48 vs. 27 months).
  • Lowest SII quartile (<492) had significantly better 84-month survival (88.4% vs. 55.1%).
  • Elevated SII independently predicted mortality; SIRI was associated with adverse events but not independently.

Conclusions:

  • Pre-procedural SII is an independent predictor of survival in CLTI patients post-revascularization.
  • SII may serve as a valuable tool for risk stratification in CLTI management.
Abstract

Keywords:
Cardiovascular outcomesChronic limb-threatening ischemiaInflammatory markersRevascularizationSystemic Immune-Inflammation Index

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