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Electrically Conductive Scaffold to Modulate and Deliver Stem Cells
05:49

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Published on: April 13, 2018

BDNF regulates pituitary stem cell engagement toward precursor state.

Kevin Sochodolsky1, Konstantin Khetchoumian1, Aurelio Balsalobre1

  • 1Laboratoire de génétique moléculaire, Institut de recherches cliniques de Montréal (IRCM), 110 Avenue des Pins Ouest, Montréal, QC H2W 1R7, Canada.

Stem Cell Reports
|July 2, 2026
PubMed
Summary

Researchers identified brain-derived neurotrophic factor (BDNF) as key in pituitary stem cell differentiation for stress response regulation. Glucocorticoids repress this process, highlighting a crucial feedback loop for pituitary-adrenal homeostasis.

Keywords:
BDNFHPA axisPOMCTpitadrenalectomydifferentiationglucocorticoid feedbackpituitary stem cellspre-corticotropestissue homeostasis

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Area of Science:

  • Endocrinology
  • Neuroscience
  • Developmental Biology

Background:

  • Tissue stem cell differentiation involves transient precursor states.
  • The role of lineage precursors in tissue development and function remains unclear.
  • Corticotrope precursors, regulating the stress response, are difficult to characterize.

Purpose of the Study:

  • To characterize pituitary corticotrope precursors.
  • To investigate the regulation of corticotrope differentiation.
  • To identify signaling pathways involved in pituitary-adrenal homeostasis.

Main Methods:

  • Utilized POMC knockout and adrenalectomized mouse models.
  • Analyzed corticotrope precursor accumulation and differentiation.
  • Investigated the role of Tpit and glucocorticoids.
  • Identified brain-derived neurotrophic factor (BDNF) signaling.

Main Results:

  • Pre-corticotrope differentiation is dependent on Tpit and repressed by glucocorticoids.
  • BDNF acts as a signal engaging pituitary stem cells toward differentiation.
  • A glucocorticoid-sensitive BDNF autocrine loop was identified in pre-corticotropes.
  • These precursors function as signaling hubs for pituitary-adrenal homeostasis.

Conclusions:

  • BDNF is a critical regulator of pituitary stem cell differentiation.
  • Glucocorticoid feedback modulates BDNF signaling to maintain homeostasis.
  • Pre-corticotrope precursors play a vital role in regulating the stress response.