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Vitamin D maintenance in postoperative patients (D-ECISIVE): a study protocol for a randomized controlled trial
Glenys Shu Wei Quak1, James Jia Dong Wang1, Candy Yap2
1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Annals of Coloproctology
|July 2, 2026
Summary
This study investigates if monthly high-dose vitamin D supplements improve muscle function and quality of life after surgery. Findings may guide postoperative vitamin D guidelines for better patient recovery.
Area of Science:
- Orthopedics
- Endocrinology
- Nutritional Science
Background:
- Vitamin D is crucial for calcium homeostasis, muscle health, and surgical recovery.
- Postoperative patients are at risk for vitamin D insufficiency, impacting muscle function and quality of life.
- Current postoperative vitamin D maintenance lacks standardized protocols.
Purpose of the Study:
- To evaluate the efficacy of monthly high-dose vitamin D (50,000 IU) supplementation in maintaining serum vitamin D levels postoperatively.
- To assess the impact of this supplementation on muscle function and quality of life compared to standard care.
Main Methods:
- A single-center, open-label, randomized controlled trial involving adults (21-65 years) with 25-hydroxyvitamin D levels between 30-50 ng/mL, 4-6 weeks post-major surgery.
- Participants randomly assigned to receive monthly 50,000 IU vitamin D3 or standard care for 6 months.
- Primary outcome: maintenance of serum 25-hydroxyvitamin D at 3 months; secondary outcomes: muscle function tests, muscle quality index, and quality of life (EQ-5D-3L).
Main Results:
- This study is designed to provide evidence on the effectiveness of high-dose monthly vitamin D supplementation in enhancing postoperative recovery.
- The results will elucidate the impact on muscle function, muscle quality, and patient-reported quality of life.
Conclusions:
- The findings could inform the development of standardized guidelines for vitamin D supplementation in surgical patients.
- This research may optimize future vitamin D intervention strategies for improved outcomes in the surgical population.
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