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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
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Identification of the HLA-B*07:02:112 Allele in a Brazilian Individual by Next-Generation Sequencing

Emerson Fernando Garcia Machado1,2, Josiane Aparecida Linhares1, Maria Eduarda Dugonski1

  • 1Laboratory of Immunogenetics, Cajuru University Hospital, Curitiba, Parana, Brazil.

HLA
|July 3, 2026
PubMed

Keywords:
HLA‐B*07:02:112new HLA allelenext‐generation sequencingsynonymous substitution

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Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.