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Related Concept Videos

Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
Opioid Receptors: Overview01:22

Opioid Receptors: Overview

Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2, D-Pen5]-enkephalin or DPDPE for...
Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...

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Related Experiment Video

Updated: Jul 4, 2026

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
07:09

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Published on: July 16, 2014

Peripheral targets for neuropathic pain.

Amirhossein Afsharipour1, Cosmin I Ciotu1, Felix J Resch1

  • 1Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.

British Journal of Pharmacology
|July 3, 2026
PubMed
Summary
This summary is machine-generated.

This review identifies key molecular targets for neuropathic pain, focusing on peripheral mechanisms. It highlights promising ion channels and novel targets, offering hope for new pain relief drugs.

Keywords:
bibliometryclinical trialnovel targetspain

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Pain Research

Background:

  • Neuropathic pain presents a major clinical challenge with limited effective treatments.
  • Current pharmacological options for symptomatic relief are insufficient.
  • Understanding molecular targets is crucial for developing better therapies.

Purpose of the Study:

  • To review molecular targets implicated in neuropathic pain, emphasizing peripheral mechanisms.
  • To analyze target occurrence in scientific literature using the IUPHAR/BPS database.
  • To classify targets into 'large', 'rising', and 'novel' categories for strategic drug development.

Main Methods:

  • Literature analysis of 'neuropathic pain' and biological targets in PubMed.
  • Utilizing the IUPHAR/BPS database for target identification.
  • Classification of targets based on literature prevalence and research trends.

Main Results:

  • Ion channels are prominent among established neuropathic pain targets.
  • The review details top 15 targets in 'large', 'rising', and 'novel' categories.
  • Analysis includes targets with approved drugs, ongoing clinical trials, and preclinical evidence.

Conclusions:

  • Ongoing clinical trials show promise for new neuropathic pain medications.
  • Expectation of novel drugs for established targets and new mechanistic approaches.
  • Advances in understanding molecular targets could lead to improved pain management strategies.