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Lung Function Decline Among Nonsmoking Adults With Periodontitis in Pakistan: A Cross-Sectional Study
Amna Afzaal1, Ruqaya Nangrejo1, Maryam Afzaal2
1Department of Physiology Baqai Medical University Karachi Pakistan.
Health Science Reports
|July 3, 2026
Summary
Poor periodontal health is linked to reduced lung function in nonsmokers. Systemic inflammation (Hs-CRP) did not mediate this association, suggesting further research is needed.
Area of Science:
- Oral Health
- Respiratory Medicine
- Inflammation Research
Background:
- Periodontitis, a chronic inflammatory oral condition, has recognized systemic effects.
- Emerging evidence suggests a link between periodontitis and respiratory health.
Purpose of the Study:
- To investigate the association between periodontitis and reduced lung function in nonsmoking adults.
- To determine if systemic inflammation, measured by high-sensitivity C-reactive protein (Hs-CRP), mediates this relationship.
Main Methods:
- Cross-sectional study of 120 nonsmoking adults (periodontitis vs. healthy controls).
- Assessed periodontal status (CPI, PPD, CAL) and lung function (FEV1, FVC, FEV1/FVC ratio).
- Measured Hs-CRP and analyzed associations and mediation using statistical models.
Main Results:
- Poorer periodontal health was negatively associated with FEV1 and FEV1/FVC ratio.
- Hs-CRP correlated positively with periodontal measures but not significantly with lung function.
- Mediation analysis did not support Hs-CRP as a significant mediator between periodontitis and lung function.
Conclusions:
- Reduced pulmonary function is observed in nonsmokers with poorer periodontal health.
- Systemic inflammation (Hs-CRP) did not mediate the link between periodontitis and lung function in this cohort.
- Further longitudinal studies are required to establish causality and the role of periodontitis in lung function decline.
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