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Valorizing ginseng residues using dimethyl ether: Recovering functional lipids and ginsenosides
Sabrinna Wulandari1, Ruqian Cao2, Jongho Choi2
1School of Chemical Engineering, Sungkyunkwan University, 2066, Seobu-Ro, Jangan-Gu, Suwon, Gyeong Gi-Do, 16419, Republic of Korea.
Journal of Ginseng Research
|July 3, 2026
Summary
Dimethyl ether (DME) efficiently extracts valuable ginseng oil from red ginseng marc (RGM). This green solvent method optimizes yield and bioactive compounds, offering a cost-effective alternative for industrial applications.
Area of Science:
- Green Chemistry
- Natural Product Extraction
- Biotechnology
Background:
- Red ginseng marc (RGM) is a byproduct rich in lipids and bioactive compounds.
- Conventional extraction methods for RGM are costly due to harsh conditions and solvent removal.
Purpose of the Study:
- To evaluate dimethyl ether (DME) as a green solvent for extracting ginseng oil from RGM.
- To optimize extraction parameters using response surface methodology (RSM).
Main Methods:
- DME was used as a solvent for ginseng oil extraction from RGM.
- Response surface methodology (RSM) analyzed the effects of temperature, pressure, and time.
Main Results:
- Optimal conditions (333 K, 7 MPa, 80 min) yielded 3.37% extraction with high ginsenoside and phenolic content.
- DME-extracted oil showed superior antioxidant activity and fatty acid methyl ester (FAME) content compared to ethanol and hexane extracts.
- DME allowed direct extraction from wet RGM, improving yield and ginsenoside content.
Conclusions:
- DME is a versatile and energy-efficient solvent for extracting bioactive ginseng oil from RGM.
- The process is suitable for both dry and wet RGM, with practical applications in food and cosmetics.
