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Related Experiment Video

Updated: Jul 4, 2026

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment
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Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Published on: April 4, 2017

Light-Driven, Phase-Locked Protein Pumping Through a Single Plasmonic Optofluidic Nanopore.

Mohammad Karbalaei Akbari1,2, Kumar Shrestha1,2, Yanbin Cui3

  • 1Department of Solid-State Sciences, Faculty of Science, Ghent University, Ghent, Belgium.

Small (Weinheim an Der Bergstrasse, Germany)
|July 3, 2026
PubMed
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This study introduces a light-driven plasmonic nanopore system that enhances protein transport. The novel optofluidic pump overcomes limitations in low concentration detection for dynamic, light-controlled single-molecule protein analysis.

Area of Science:

  • Nanotechnology
  • Biophysics
  • Optics

Background:

  • Protein transport in nanopores is limited by electrical double layers (EDLs) and weak electrophoretic forces at low concentrations.
  • Existing methods struggle with efficient analyte manipulation in nanoscale systems.

Purpose of the Study:

  • To demonstrate a light-driven, phase-locked protein pumping mechanism using plasmonic nanopores.
  • To overcome low analyte concentration limitations in nanopore transport.

Main Methods:

  • Fabrication of a ~20 nm plasmonic nanopore in an ultrathin (InxGa1-x)2O3 membrane with Ag nanodomains.
  • Utilized 488-530 nm light excitation to generate plasmonic resonances and hot-carrier surface charging.
  • Employed static-dynamic fluorescence reconstruction and fluorescence-ionic measurements.
Keywords:
optofluidic dynamicsoptofluidic pumpingphoto‐EDL modulationplasmonic gatingprotein trans‐molecular pumpingsolid‐state nanopore

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Last Updated: Jul 4, 2026

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment
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Published on: April 4, 2017

Trapping of Micro Particles in Nanoplasmonic Optical Lattice
07:20

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Published on: September 5, 2017

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09:33

Monitoring Conformational Dynamics of Single Unmodified Proteins using Plasmonic Nanotweezers

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Main Results:

  • Achieved significantly increased interfacial EDL capacitance (~220 µF·cm⁻²) and reduced protein entry barrier (<3 kBT).
  • Observed a concentration-dependent transition from Brownian diffusion to a photo-EDL conduction column funneling proteins.
  • Demonstrated ~10x fluorescence enhancement and increased optical pumping rates under pulsed excitation.

Conclusions:

  • Plasmonic nanopores function as programmable optofluidic pumps for dynamic, light-controlled single-molecule protein transport.
  • This mechanism enhances protein transport efficiency, particularly at low concentrations.