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Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
Published on: July 31, 2017
Radiomics-based intratumoral heterogeneity subtypes in IDH wild-type glioblastoma with pathomic and transcriptomic
Xin Duan1,2, Wenju Niu1,2, Xuan Li1,2
1Department of Radiology, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
BMC Cancer
|July 3, 2026
Summary
Radiomics-based intratumoral heterogeneity (RITH) subtypes in IDH-wild-type glioblastoma (IDH-wt GBM) show distinct survival outcomes. The High RITH subtype indicates poorer prognosis and links to specific pathomic and transcriptomic profiles.
Area of Science:
- Neuro-oncology
- Radiomics
- Genomics
Background:
- IDH-wild-type glioblastoma (IDH-wt GBM) presents significant intratumoral heterogeneity, complicating treatment and prognosis.
- Understanding this heterogeneity is crucial for improving patient outcomes.
Purpose of the Study:
- To identify radiomics-based intratumoral heterogeneity (RITH) subtypes in IDH-wt GBM.
- To evaluate the prognostic significance and associated pathomic and transcriptomic characteristics of these RITH subtypes.
Main Methods:
- Radiomic features were extracted from CE-T1 and T2-FLAIR MRI scans in 333 IDH-wt GBM patients.
- Partitioning around medoids (PAM) clustering was used to define RITH subtypes.
- Survival analysis, pathomic feature extraction (PathScore), and RNA-seq analysis were performed.
Main Results:
- Two distinct RITH subtypes were identified, with significant differences in overall survival (OS).
- The High RITH subtype was independently associated with shorter OS and showed significant differences in PathScore and transcriptomic profiles.
- Eleven candidate hub genes related to immune-inflammatory pathways were identified.
Conclusions:
- RITH subtypes represent distinct imaging phenotypes in IDH-wt GBM.
- These subtypes correlate with prognosis, histopathological features, and underlying biological processes, offering potential for non-invasive assessment.
