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Overcoming Unresponsiveness in Experimental Autoimmune Encephalomyelitis (EAE) Resistant Mouse Strains by Adoptive Transfer and Antigenic Challenge
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Overcoming Unresponsiveness in Experimental Autoimmune Encephalomyelitis (EAE) Resistant Mouse Strains by Adoptive Transfer and Antigenic Challenge

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Response to Xue et al, "Defining super-responders is not the same as predicting rituximab response in pemphigus"

Zhili Wu1, Jiefeng Jiang1, Keyun Duan1

  • 1The First School of Clinical Medicine, Southern Medical University, Guangzhou, China; Dermatology Hospital, Southern Medical University, Guangzhou, China.

Journal of the American Academy of Dermatology
|July 4, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
corticosteroidspemphiguspredictorrituximabrituximab-refractorysuper-responder

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Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

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