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Defective PdMo metallene with efficient catalase-like activity for sensitive immunoassay.

Chuan Tian¹, Bin Yang², Miaolin Yin³

¹Department of Interventional Medical Center, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.

Analytica Chimica Acta

|July 4, 2026

Summary

Researchers developed defect-rich palladium-molybdenum nanosheets (d-PdMoene) with enhanced catalase-like activity for sensitive biosensing. This breakthrough enables portable point-of-care testing devices for accurate analyte detection.

Keywords:

CAT-Like activity Defect engineering Metallene Nanozyme Pressure-based immunoassay

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Published on: July 28, 2016

Area of Science:

Materials Science
Nanotechnology
Analytical Chemistry

Background:

Nanozyme-based biosensors offer high potential for trace analyte detection.
Rational design of high-performance nanozymes is critical for advanced immunoassays and point-of-care testing (POCT).
Developing efficient nanozymes remains a significant challenge.

Purpose of the Study:

To synthesize and characterize novel nanozyme materials for enhanced biosensing.
To investigate the catalytic properties and mechanism of the synthesized nanozymes.
To demonstrate the application of the nanozyme in a portable immunoassay sensor.

Main Methods:

Synthesis of ultrathin palladium-molybdenum metallene nanosheets (d-PdMoene) with a high density of defects.
Evaluation of catalase-like activity (CAT-like activity) through H2O2 decomposition.
Theoretical calculations (e.g., DFT) to understand electronic structure and catalytic mechanisms.
Development of a pressure-based immunoassay sensor for prostate-specific antigen (PSA).

Main Results:

Successfully synthesized d-PdMoene with superior CAT-like activity.
Theoretical calculations confirmed enhanced H2O2 adsorption and easier O2 release due to optimal electronic configuration and defect sites.
The generated O2 produced measurable pressure changes, enabling portable detection.
A PSA immunoassay sensor demonstrated high sensitivity and selectivity using d-PdMoene.

Conclusions:

Defect-rich d-PdMoene exhibits excellent nanozyme activity for biosensing applications.
The study provides a framework for designing high-performance nanozymes.
This work paves the way for developing practical, portable POCT devices.