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LLM research on public biosignals data is needed to protect patients
James Anibal1,2, Jasmine Gunkel3, Hannah Huth4
1Center for Interventional Oncology, NIH Clinical Center, NIH, Bethesda, MD, USA. anibal.james@nih.gov.
NPJ Digital Medicine
|July 4, 2026
Summary
Public biosignals datasets are crucial for advancing artificial intelligence (AI) in medicine. This study offers recommendations for releasing biosignals data to ethically support large language model (LLM) research and innovation.
Area of Science:
- Biomedical informatics
- Artificial intelligence in medicine
- Digital health
Background:
- Large language models (LLMs) are advancing AI capabilities, presenting new medical applications.
- Public biosignals datasets are essential for developing safe, innovative digital health tools and establishing research benchmarks.
- Current data use agreements often restrict LLM research, hindering progress.
Purpose of the Study:
- To propose recommendations for the ethical release of public biosignals datasets.
- To facilitate research and development of large language models in the medical field.
- To ensure public data supports AI innovation while maintaining ethical standards.
Main Methods:
- Analysis of existing data use agreements and their impact on LLM research.
- Development of a framework for ethical data release.
- Formulation of best practices for public biosignals dataset curation.
Main Results:
- Identification of specific restrictions in current data use agreements that impede LLM studies.
- A set of actionable recommendations for policymakers and data curators.
- Guidelines for balancing data accessibility with ethical considerations and privacy.
Conclusions:
- Ethical and strategic release of public biosignals data is vital for advancing AI in medicine.
- Implementing the proposed recommendations will foster LLM research and the development of novel digital health solutions.
- Ensuring data accessibility while upholding ethical standards is key to unlocking the full potential of AI in healthcare.
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