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Related Concept Videos

Allergic Reactions02:06

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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

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Related Experiment Video

Updated: Jul 7, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
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Pandemic-Associated Sensitization Patterns and Burden in Chinese Children with Allergic Rhinitis: A Retrospective

Longli Huang1, Xinfeng Zhao1, Jun Zhou1

  • 1Department of Clinical Laboratory, Hangzhou Children's Hospital, Hangzhou, Zhejiang, People's Republic of China.

Journal of Asthma and Allergy
|July 6, 2026
PubMed
Summary

The COVID-19 pandemic altered allergen sensitization in children with allergic rhinitis (AR). Post-pandemic, increased inhalant allergen sensitization and complexity were observed, impacting risk stratification for pediatric AR.

Keywords:
COVID-19 pandemicallergen sensitizationallergic rhinitischildrenco-sensitizationspecific IgE

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Last Updated: Jul 7, 2026

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Area of Science:

  • Pediatric Allergy and Immunology
  • Environmental Health
  • Epidemiology

Background:

  • The COVID-19 pandemic and related interventions may have changed children's exposures.
  • Limited data exist on how allergen sensitization patterns in pediatric allergic rhinitis (AR) changed during different pandemic phases.

Purpose of the Study:

  • To evaluate phase-specific shifts in serum allergen-specific immunoglobulin E (sIgE) sensitization, intensity, co-sensitization, and burden among children with AR in Eastern China.
  • To compare allergen sensitization patterns across pre-pandemic, lockdown, and post-lockdown periods.

Main Methods:

  • Analysis of 12,702 children (0-18 years) with diagnosed AR undergoing sIgE testing for 19 allergens (2018-2024).
  • Comparison of sensitization across pre-pandemic (2018-2019), lockdown (2020-2022), and post-lockdown (2023-2024) phases.
  • Statistical analysis using Pearson's chi-squared test, Fisher's exact test, and multivariable logistic regression, adjusting for age, sex, and season.

Main Results:

  • Divergent sensitization trajectories observed between pre-pandemic, lockdown, and post-lockdown phases.
  • Increased sensitization to inhalant allergens and decreased sensitization to certain food allergens noted, with a rise in seafood allergens post-lockdown.
  • Higher odds of sensitization to indoor, outdoor, and seafood allergens, alongside increased strong-positive responses and co-sensitization patterns post-lockdown.

Conclusions:

  • Children with AR exhibited distinct inhalant and food allergen sensitization patterns across pandemic phases, with increased intensity and complexity post-lockdown.
  • Findings suggest phase-specific environmental associations rather than direct pandemic causality.
  • Results can inform post-pandemic risk stratification for pediatric AR, emphasizing inhalant allergen control and careful interpretation of food allergen sIgE results.