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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...

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Related Experiment Video

Updated: Jul 7, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Multiallergen Immunotherapy for Polysensitized Patients with Allergic Rhinitis: A Systematic Review and

Yu Shi1, Zhouxian Pan1, Xinyu Tian1

  • 1Department of Allergy, Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing, People's Republic of China.

Journal of Asthma and Allergy
|July 6, 2026
PubMed
Summary
This summary is machine-generated.

Multiallergen allergen immunotherapy (AIT) shows comparable efficacy and safety to single-allergen AIT for allergic rhinitis in polysensitized patients. Dual-allergen approaches may offer benefits, but more standardized trials are needed.

Keywords:
allergen immunotherapyallergic rhinitismultiallergen immunotherapypolysensitizationsystematic review and meta-analysis

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Last Updated: Jul 7, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

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Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Area of Science:

  • Immunology
  • Allergology
  • Clinical Trials

Background:

  • Polysensitization affects 80% of allergic patients.
  • The use of multi-allergen formulations in allergen immunotherapy (AIT) for polysensitized individuals is debated.

Purpose of the Study:

  • To assess the clinical effectiveness and safety of multiallergen AIT in polysensitized patients with allergic rhinitis (AR).

Main Methods:

  • A systematic review and meta-analysis of randomized clinical trials and non-randomized studies.
  • Searched PubMed, Embase, Web of Science, and Cochrane Library for studies up to June 5, 2025.
  • Included 7 RCTs and 7 non-randomized studies.

Main Results:

  • Multiallergen AIT significantly reduced symptom and medication scores compared to placebo.
  • No significant difference in symptom score changes compared to single-allergen AIT, but slight superiority in medication scores.
  • Both scores were significantly reduced at the last follow-up compared to single-allergen treatment.
  • Multiallergen AIT demonstrated a safer profile in randomized studies.
  • Equivalent immune tolerance and type 2 immune response modulation compared to single-allergen AIT.

Conclusions:

  • Multiallergen AIT offers comparable efficacy, safety, and immunological modulation to single-allergen AIT for polysensitized AR patients.
  • Dual-allergen AIT may provide optimized benefits in specific cases.
  • Study heterogeneity highlights the need for standardized trials.