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Modeling Healthy and Dysbiotic Vaginal Microenvironments in a Human Vagina-on-a-Chip
Published on: February 16, 2024
Vaginal Microecological Imbalance, Human Papillomavirus Infection, and Cervical Carcinogenesis: Mechanisms and
Wenjun Gao1, Yuqin Liu1, Qianyin Wang1
1Department of Gynaecology and Obstetrics, Qinghai Red Cross Hospital, Xining, Qinghai Province, 810000, People's Republic of China.
Abstract:
The vaginal microecology serves as a critical barrier for female reproductive tract health, with its dysbiosis being closely linked to persistent HPV infection and the initiation and progression of cervical cancer. This review systematically outlines the composition and functions of the vaginal microbiota and delves into the multifaceted mechanisms by which microecological imbalance promotes human papillomavirus (HPV) acquisition, persistence, and oncogenic transformation. These mechanisms include dysregulation of local and systemic immunity, chronic inflammation, alterations in microbial metabolites, and disruption of the epithelial barrier. Furthermore, the article synthesizes recent advancements in novel strategies for cervical cancer prevention, auxiliary diagnosis, and treatment based on microecological modulation. The overarching aim is to provide a consolidated theoretical foundation and identify potential therapeutic targets for the precise prevention and management of cervical cancer, highlighting the pivotal role of maintaining or restoring vaginal microbial homeostasis.
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