Multiscale rational construction strategy for polyphenol self-assembled delivery systems: from nanoscale to...

Area of Science:

• Biomaterials Science
• Nanotechnology
• Drug Delivery

Background:

• Natural polyphenols possess potent antioxidant, anti-inflammatory, and antibacterial properties.
• Polyphenols' hydroxyl groups facilitate complexation via non-covalent interactions, enabling self-assembly.
• Their interfacial properties are key for constructing multiscale delivery systems.

Purpose of the Study:

• To systematically review polyphenol-based microscale delivery systems.
• To discuss their self-assembly, preparation, and therapeutic applications.
• To highlight advances and future directions in polyphenol biomaterials.

Main Methods:

• Review of literature on polyphenol self-assembly and microscale systems.
• Analysis of various delivery systems: coacervate droplets, Pickering emulsions, microcapsules, microparticles, and modified microbes/cells.
• Discussion of preparation methods, functional characteristics, and therapeutic uses.

Main Results:

• Polyphenol self-assembly enables diverse microscale delivery systems (coacervates, emulsions, capsules, particles).
• These systems demonstrate significant potential in disease treatment and biomedical applications.
• Advances in polyphenol-based biomaterials are rapidly expanding therapeutic possibilities.

Conclusions:

• Polyphenol-based microscale delivery systems offer promising avenues for advanced therapeutics.
• Further research into polyphenol self-assembly will drive the development of next-generation biomaterials.
• These systems hold potential for pharmaceuticals, food, and cosmetics industries.