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Identifying High-Risk Patients With Cerebral Venous Thrombosis for Early Intervention
Pichatorn Suppakitjanusant1,2, Myriam Vijil1,2, Chanaka Kahathuduwa1,2
1Covenant Medical Center, Lubbock, TX (P.S., M.V., C.K., K.H., Saif Bushnaq).
Stroke (Hoboken, N.J.)
|July 6, 2026
Summary
The CLOTS-EVT score effectively predicts early deterioration in cerebral venous thrombosis patients. This tool aids in risk stratification and guides treatment decisions for better patient outcomes.
Area of Science:
- Neurology
- Vascular Medicine
- Medical Diagnostics
Background:
- Cerebral venous thrombosis (CVT) diagnosis is challenging due to varied symptoms.
- Early identification of patients at risk of deterioration is crucial.
- The CLOTS-EVT score was developed to predict early deterioration in CVT.
Purpose of the Study:
- To externally validate the CLOTS-EVT score for predicting early deterioration in CVT.
- To assess the score's correlation with functional outcomes and hospital stay.
Main Methods:
- Retrospective analysis of 80 adult CVT patients across 12 centers (2015-2017).
- Application of the 10-point CLOTS-EVT score using clinical, lab, and imaging data.
- Evaluation of predictive performance (sensitivity, specificity, AUC) and correlation with outcomes.
Main Results:
- A CLOTS-EVT score ≥4 predicted early deterioration with 82% sensitivity and 61% specificity (AUC=0.718).
- Higher scores correlated with longer hospital stays (r=0.325) and worse functional outcomes (r=0.363).
- Common symptoms included headache; risk factors varied, with 10% undergoing endovascular therapy.
Conclusions:
- The CLOTS-EVT score is a practical tool for risk stratification in cerebral venous thrombosis.
- It aids in identifying patients needing timely intervention, potentially including venous thrombectomy.
- The score combines readily available clinical, laboratory, and imaging data for improved patient management.
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