Mechanochemical Piezoelectric Catalysis: Advancing the Hydrogenation of Alkenes
Zixi Ai1, Mengting Liu1, Xiaohong Wang1
1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Abstract:
Alkene hydrogenation reactions are essential processes widely utilized across diverse scientific fields for the production of pharmaceuticals, natural products, and various functional materials. Current strategies (e.g., metal hydrogen atom transfer [mHAT], photo/electrochemistry) consistently necessitate compromises, invariably involving transition metals, pressurized H2, or solvent-intensive conditions. Herein, we report a mechanochemical hydrogenation reaction of both activated and unactivated alkenes via piezoelectric catalysis under conditions that are free from transition-metals, H2 gas, and solvents. This approach exhibits good compatibility with various functional groups and demonstrates a broad substrate scope. In addition, the hydrogenation of bioactive molecule derivatives for modification purposes highlights its potential applications in the pharmaceutical industry. Based on mechanistic investigations, we propose a potential mechanism for the alkene hydrogenation via piezoelectric catalysis.
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