Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 8, 2026

A High Throughput in situ Hybridization Method to Characterize mRNA Expression Patterns in the Fetal Mouse Lower Urogenital Tract

A High Throughput in situ Hybridization Method to Characterize mRNA Expression Patterns in the Fetal Mouse Lower Urogenital Tract

Published on: August 19, 2011

Spatial transcriptomic mapping of postnatal mouse uterine development.

M Fairuz B Jamaluddin¹, Shafiq M Syed¹, Riazuddin Mohammed²

¹School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales 2308, Australia.

Proceedings of the National Academy of Sciences of the United States of America

|July 6, 2026

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Upcycled battery-derived MnO<sub>2</sub> for ultrafast lead removal from wastewater.

RSC advances·2026

Same author

Efficacy and Safety of the Dual Glucagon-Like Peptide-1 and Glucagon Receptor Agonist Mazdutide in Predominantly Chinese Adults With Obesity and/or Type 2 Diabetes: A Systematic Review and Meta-Analysis.

Diabetes, obesity & metabolism·2026

Same author

From Emergence to Resurgence: Evolutionary Dynamics of Chikungunya Virus in Bangladesh, 2008-2025.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2026

Same author

Zeaxanthin Modulates Early Metabolic and Inflammatory Responses in db/db Mice: Associations with Intestinal Lipid Handling and Gut Microbiome Remodeling.

Biomolecules·2026

Same author

Knowledge, Attitude and Practice of Nursing Students on Antibiotic Use and Resistance in Bangladesh.

SAGE open nursing·2026

Same author

Assessing reach and perceptions of hygiene behaviour change interventions for people with disabilities and older adults: Multi-country matched cross-sectional study.

International journal of hygiene and environmental health·2026

This study maps mouse uterine development, revealing endometrial glands form from luminal epithelium via transcriptional changes, not fixed progenitors. Spatial signaling networks coordinate this complex gland formation process.

Area of Science:

Reproductive Biology
Developmental Biology
Genomics

Background:

Postnatal uterine development involves intricate epithelial and stromal organization.
Understanding the spatial integration of transcriptional programs is crucial but limited.

Purpose of the Study:

To create a spatially resolved transcriptomic map of the developing mouse uterus.
To elucidate the mechanisms of endometrial gland formation (adenogenesis) and maturation.

Main Methods:

Spatially resolved transcriptomics combined with histology, proteomics, and genetic models.
In situ transcriptomics across postnatal days 3-21 in mice.
Functional genetic assays to validate signaling pathway roles.

Main Results:

Keywords:

endometrium female fertility organoids spatial uterus

More Related Videos

Mouse in Utero Electroporation: Controlled Spatiotemporal Gene Transfection

Mouse in Utero Electroporation: Controlled Spatiotemporal Gene Transfection

Published on: August 15, 2011

Related Experiment Videos

Last Updated: Jul 8, 2026

A High Throughput in situ Hybridization Method to Characterize mRNA Expression Patterns in the Fetal Mouse Lower Urogenital Tract

A High Throughput in situ Hybridization Method to Characterize mRNA Expression Patterns in the Fetal Mouse Lower Urogenital Tract

Published on: August 19, 2011

Mouse in Utero Electroporation: Controlled Spatiotemporal Gene Transfection

Mouse in Utero Electroporation: Controlled Spatiotemporal Gene Transfection

Published on: August 15, 2011

Endometrial glands arise from luminal epithelium through progressive transcriptional reprogramming.
Distinct spatial compartmentalization of signaling pathways (e.g., Wnt, retinoic acid, hedgehog) during gland development.
Epithelial Wnt signaling is vital for prepubertal gland establishment but not postpartum regeneration.

Conclusions:

Provides a comprehensive spatial framework for uterine gland development.
Reveals how compartmentalized signaling networks orchestrate postnatal uterine morphogenesis.
Highlights the dynamic nature of epithelial progenitor cells during tissue formation.