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Carboxymethyl chitosan-based multifunctional hydrogel loaded with ginseng stem cell exosomes promotes severe burn
Ran Ding1, Yongming Wang2, Zhiqing Long3
1Department of Radiation Oncology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510060, China; South China University of Technology International Campus, No. 777, Xingye Avenue East, Panyu District, Guangzhou 511442, PR China.
Abstract:
Severe burns cause excessive inflammation and immune dysregulation that delay healing and increase infection risk. Here, we developed an injectable self-healing hydrogel (CMCS/OHA/Exo, "Exo-gel") incorporating ginseng callus stem-cell-derived exosomes to promote burn repair. The hydrogel rapidly formed via Schiff-base crosslinking, exhibited excellent injectability, mechanical resilience, and sustained exosome release. Exosomes (∼140 nm) were rich in bioactive lipids and miRNAs related to angiogenesis and immune regulation. In vitro, Exo-gel enhanced cell viability, reduced LPS-induced reactive-oxygen species (ROS), and significantly downregulated IL-1β, iNOS, IL-6, and TNF-α expression. In vivo, Exo-gel accelerated wound closure, promoted re-epithelialization, angiogenesis, and collagen remodeling, yielding superior tissue repair. This renewable, antibiotic-sparing biomaterial offers a promising therapeutic platform for severe burn treatment.
