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Updated: Jul 8, 2026

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia
Published on: November 10, 2023
The gut microbiota-bone marrow axis: an emerging role in chemotherapy-induced myelosuppression
Li Gong1,2, Yeqi Wang1, Yongsheng Li3
1Key Laboratory of Biorheological Science and Technology of Ministry of Education, Bioengineering College, Chongqing University, Chongqing, China.
Abstract:
Accumulating evidence indicates that gut microbiota extensively modulates the toxicity of chemotherapeutics. However, the role of microbiota in chemotherapy-induced myelosuppression (CIM) remains poorly characterized. This review synthesizes the pivotal role of gut microbiota in regulating hematopoiesis, summarizes recent findings on the links between gut microbiota and CIM, and discusses emerging strategies for alleviating CIM through microbiota modulation. Our analysis pinpoints key gaps and novel insights for targeted CIM therapies.
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