Related Experiment Video
Updated: Jul 8, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Pediatric Psoriasis: Comorbidities, Treatment Challenges and Unmet Needs
Marc Hernández-Santacana1, Pablo Balado-Simó1, Miguel Mansilla-Polo2,3
1Dermatology Department, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.
Dermatology and Therapy
|July 6, 2026
Summary
Pediatric psoriasis, a chronic inflammatory condition, presents significant comorbidities and quality of life issues. Advances in biologic therapies offer hope, but challenges in access, long-term data, and treatment algorithms persist for children and adolescents.
Area of Science:
- Dermatology
- Immunology
- Pediatrics
Background:
- Pediatric psoriasis is a chronic, immune-mediated disease impacting children and adolescents.
- It is linked to metabolic, psychological, and inflammatory comorbidities, affecting quality of life for patients and caregivers.
Purpose of the Study:
- To review current evidence on comorbidities, treatment challenges, unmet needs, and future directions in pediatric psoriasis.
Main Methods:
- This narrative review synthesizes available data on pediatric psoriasis and its associated conditions.
- It examines therapeutic advancements, challenges, and research gaps.
Main Results:
- Children with psoriasis face increased risks of obesity, cardiometabolic factors, and psychological issues like depression and anxiety.
- Psoriatic arthritis requires early detection; while biologics have advanced treatment, challenges include access, age restrictions, and limited long-term safety data.
- Gaps exist in pediatric drug development, evidence beyond plaque psoriasis, and understanding long-term comorbidity trajectories.
Conclusions:
- Despite progress, significant unmet needs remain in pediatric psoriasis care, including standardized treatment algorithms and long-term safety evaluations.
- Future personalized approaches may arise from understanding immunopathogenic differences and biomarker research.
- Addressing these gaps is crucial for optimizing patient-centered care for pediatric psoriasis patients.
Related Concept Videos
01:23Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
01:24Pharmacokinetics in Pediatric Patients: Drug Metabolism
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
01:26Pharmacokinetics in Pediatric Patients: Drug Excretion
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
01:27Acne Infection
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
01:17Pharmacokinetics in Pediatric Patients: Drug Distribution
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
01:20Asthma: Pathogenesis and Management
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.