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Curcumin and Cognitive Health: Insights from Randomized Controlled Trials
Bhagavathi Sundaram Sivamaruthi1,2,3, Chaiyavat Chaiyasut2, Periyanaina Kesika1,2
1Office of Research Administration, Chiang Mai University, Chiang Mai, 50200, Thailand.
Current Pharmaceutical Design
|July 7, 2026
Summary
Curcumin supplementation shows promise for enhancing cognitive function, including memory and attention, in adults. Further research is needed to confirm its benefits and optimal use.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Curcumin exhibits antioxidant and anti-inflammatory properties, suggesting neuroprotective potential.
- Cognitive decline is a growing concern, necessitating effective interventions.
Purpose of the Study:
- To review Randomized Controlled Trials (RCTs) on curcumin's impact on adult cognitive function.
- To assess the efficacy of various curcumin formulations and dosages.
Main Methods:
- Systematic review of RCTs evaluating curcumin supplementation.
- Analysis of cognitive outcomes, neuroinflammatory markers, and brain imaging data.
Main Results:
- Curcumin supplementation, particularly nano-formulations, improved cognitive domains like memory and attention.
- Benefits were observed in working memory, mood, and cerebral blood flow, especially in older adults.
- Some studies indicated reduced neuroinflammation and amyloid/tau deposition.
Conclusions:
- Curcumin demonstrates potential as a cognitive enhancer in humans.
- Heterogeneity in study designs necessitates further large-scale, standardized RCTs.
- Optimal dosing and efficacy across diverse populations require further investigation.
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