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Hypergammaglobulinemic Purpura of Waldenström With Primary and Autoimmune Associations
Rebecca Colwell1, Justin Endo1, Daniel Bennett1
1Dr. Colwell is from Marshfield Clinic Health System, Marshfield, Wisconsin. Drs. Endo, Bennett, and Keenan are from the School of Medicine and Public Health, University of Wisconsin, Madison.
Abstract:
Hypergammaglobulinemic purpura of Waldenström (HGPW) is a rare chronic purpuric eruption, usually on the lower legs, associated with polyclonal hypergammaglobulinemia, elevated erythrocyte sedimentation rate, and IgG and IgA rheumatoid factor, and can be primary or secondary to autoimmune disease. In this article, we present 2 cases of HGPW. Thorough evaluation and rheumatology follow-up are recommended, with treatment from conservative measures to systemic agents for frequent or painful flares.
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