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Association between perioperative blood transfusion and survival outcomes after radical cystectomy for bladder cancer
R Monsonís Usó1, P Ponce Blasco1, Á Canos Nebot1
1Servicio de Urología, Hospital General Universitario de Castellón, Castellón, Spain.
Actas Urologicas Espanolas
|July 7, 2026
Summary
Perioperative blood transfusion (BT) in radical cystectomy (RC) patients is linked to poorer survival outcomes. While not tied to early mortality, strategies to minimize transfusions may improve patient management.
Area of Science:
- Urology
- Oncology
- Surgical Outcomes
Background:
- Perioperative blood transfusion (BT) is a debated prognostic factor in radical cystectomy (RC) for bladder cancer.
- This study evaluates the association between BT and patient outcomes in a contemporary RC series.
Purpose of the Study:
- To assess the impact of perioperative blood transfusion on short- and long-term outcomes in patients undergoing radical cystectomy for bladder cancer.
Main Methods:
- Retrospective analysis of 200 patients undergoing RC between 2017 and 2024.
- Collected demographic, perioperative, and pathological data.
- Analyzed 30-day mortality, overall survival (OS), and cancer-specific survival (CSS) using Kaplan-Meier and Cox regression models.
Main Results:
- 105 patients (52.5%) received perioperative BT.
- BT was significantly associated with worse OS (HR 3.28) and CSS (HR 5.33).
- BT was also linked to increased 30-day mortality (OR 10.88), though this was not independent in multivariable analysis.
Conclusions:
- Perioperative blood transfusion is associated with worse overall and cancer-specific survival post-RC.
- BT was not independently associated with 30-day mortality after adjustment.
- Optimizing preoperative anemia and reducing transfusion needs may enhance perioperative management.
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