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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: Jul 9, 2026

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
10:46

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

Published on: September 13, 2022

Aptamer Circuit-Engineered Bio-Nanovesicles With Self-Promoted Tumor-Targeting Loop for Efficient Immunogenic

Shuxuan Shao1, Cao Zhang1, Wei Du2

  • 1Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing, FuRong Laboratory, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, China.

Small Methods
|July 8, 2026
PubMed
Summary

This study introduces a novel aptamer-guided extracellular vesicle (EV) system for targeted chemotherapy. The system enhances drug delivery to tumors by amplifying targeting signals and inducing immunogenic cell death for improved cancer treatment.

Keywords:
DNA nanotechnologyaptamercancer therapyextracellular vesicleimmunogenic cell death

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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

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Last Updated: Jul 9, 2026

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
10:46

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

Published on: September 13, 2022

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Therapy

Background:

  • Targeted drug delivery is crucial for effective chemotherapy, minimizing side effects.
  • Extracellular vesicles (EVs) show promise as drug carriers but lack sufficient tumor-targeting ability.
  • Developing advanced strategies to enhance EV tumor specificity is essential.

Purpose of the Study:

  • To design an aptamer-based cascade recognition system to improve EV tumor targeting.
  • To engineer a self-promoted targeting loop to amplify drug delivery to cancer cells.
  • To evaluate the therapeutic efficacy of this enhanced EV system in cancer treatment.

Main Methods:

  • Constructed an aptamer circuit for sequential signal transduction and cascade recognition.
  • Utilized Doxorubicin Hydrochloride (DOX)-loaded EVs for drug delivery.
  • Investigated the role of PDL1 marker upregulation in tumor targeting.
  • Assessed the induction of immunogenic cell death (ICD) and anti-tumor immune response.

Main Results:

  • The aptamer circuit enabled preferential binding of EVs to cancer cells over non-cancerous cells.
  • DOX release triggered a self-promoted targeting loop, upregulating PDL1 and enhancing tumor accumulation.
  • The engineered EVs successfully induced ICD and stimulated an anti-tumor immune response.
  • Improved therapeutic outcomes were observed with the vesicle-based drug carrier.

Conclusions:

  • A self-promoted tumor-targeting strategy for EV-based carriers was successfully developed.
  • Coupling cascade recognition and a tumor-targeting loop significantly enhances therapeutic effects.
  • This approach offers a promising strategy for immunogenic chemotherapy and cancer treatment.