Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Excluding Anti-HLA-C and -DP Antibodies From the Allocation System on Kidney Transplant Access.

HLA·2026
Same author

Development of a predictive model for postoperative body mass index and diabetes outcomes after metabolic bariatric surgery: retrospective cohort study.

BJS open·2026
Same author

Delayed graft function and long-term outcomes after deceased donor kidney transplantation: insights from mate-kidney analysis.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same author

Mechanisms of the Indirect Effects of CMV Infection in Solid Organ Transplant Recipients: A Narrative Review.

Journal of clinical medicine·2026
Same author

Infrared Temperature Monitoring in Vascularized Flaps with Simulated Arterial and Venous Thrombosis: An Animal Study.

Journal of reconstructive microsurgery·2026
Same author

Under-enrollment in rare kidney disease trials: lessons learned from the PRIVENT recurrent FSGS.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026

Related Experiment Video

Updated: Jul 9, 2026

Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation
08:11

Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation

Published on: June 13, 2025

Renal Function Decline After Vascularized Composite Allotransplantation.

Gabriel Ouellet1,2, Claudia Sardu3, Jean Kanitakis4

  • 1Department of Transplantation, Nephrology and Clinical Immunology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.

Transplantation Direct
|July 8, 2026
PubMed
Summary

Vascularized composite allotransplantation (VCA) recipients experience kidney function decline post-transplant. While tacrolimus levels didn

More Related Videos

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET
17:13

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET

Published on: April 28, 2013

Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research
09:36

Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research

Published on: April 26, 2019

Related Experiment Videos

Last Updated: Jul 9, 2026

Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation
08:11

Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation

Published on: June 13, 2025

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET
17:13

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET

Published on: April 28, 2013

Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research
09:36

Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research

Published on: April 26, 2019

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Immunosuppression

Background:

  • Chronic kidney disease (CKD) is a significant complication in nonrenal transplant recipients, impacting morbidity and mortality.
  • Vascularized composite allotransplantation (VCA) requires lifelong immunosuppression, similar to solid organ transplantation.
  • The specific impact of VCA on renal function requires further investigation.

Purpose of the Study:

  • To investigate the renal function in recipients of vascularized composite allotransplantation (VCA).
  • To assess the incidence and progression of chronic kidney disease (CKD) in VCA recipients.
  • To identify potential risk factors associated with renal function decline in VCA recipients.

Main Methods:

  • A multicenter study involving 70 VCA recipients (upper extremity, face, penis transplants) with a median follow-up of 8 years.
  • Collection of pretransplant and posttransplant clinical data and sera.
  • Calculation of estimated glomerular filtration rate (eGFR) using the CKD Epidemiology Collaboration 2021 formula.

Main Results:

  • A significant decrease in median eGFR was observed by 3 months post-transplant (78.42 mL/min) compared to pretransplant levels (105.36 mL/min).
  • During follow-up, 17.1% of patients had a ≥50% eGFR decline, 10.9% progressed to CKD, and 4.7% developed end-stage kidney disease.
  • No statistically significant correlation was found between tacrolimus levels and eGFR decline, despite higher levels at 3 months.

Conclusions:

  • Renal function declines in most VCA recipients, though the decline is less severe than in nonrenal solid organ transplant recipients.
  • While a direct correlation between tacrolimus and renal decline was not established, minimizing calcineurin inhibitor exposure is recommended.
  • Strategies to avoid nephrotoxic agents are crucial for preserving long-term kidney function in VCA recipients.