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Updated: Jul 10, 2026

Implantation of Optoelectronic Devices in the Rodent Spinal Cord
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Implantation of Optoelectronic Devices in the Rodent Spinal Cord

Published on: July 12, 2024

Implantable bioelectronic outlet.

Hyung Joon Shim1, Liang Ma2, Jose Ferrero Lopez2

  • 1Department of Electrical Engineering, University of California, Irvine, CA 92697, USA.

Science Advances
|July 8, 2026
PubMed
Summary
This summary is machine-generated.

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A new implantable bioelectronic outlet (IBO) offers a durable, tissue-like interface for long-term electronic connections. This soft device enables reliable, on-demand power and signal transmission for implanted bioelectronics.

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Neuroscience

Background:

  • Reliable long-term electrical interfaces are crucial for implanted bioelectronics used in chronic diagnostics and therapeutics.
  • Existing interfaces often face challenges with durability, tissue integration, and consistent signal/power transmission.

Purpose of the Study:

  • To introduce and evaluate the implantable bioelectronic outlet (IBO) as a novel solution for stable, long-term electrical interfacing with bioelectronic implants.
  • To demonstrate the IBO's capability for bidirectional signal and power transfer in chronic implantation scenarios.

Main Methods:

  • Development of a soft, tissue-like electronic interface using a conducting polymer-coated polymer matrix jacketed with a hydrophobic elastomer.
  • Chronic implantation studies in small and large animal models to assess functionality, durability, and tissue response over one year.

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Last Updated: Jul 10, 2026

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  • Validation of high-fidelity signal transmission (neurophysiological, digital) and power delivery (low-voltage, high-current).

    • Main Results:

    • The IBO maintained functionality for over one year post-implantation with minimal observed tissue effects.
    • Demonstrated high-fidelity, bidirectional transmission of various signals, including neurophysiological data and high-speed digital data.
    • Successfully enabled efficient high-current power delivery and low-voltage neurostimulation protocols.

    Conclusions:

    • The implantable bioelectronic outlet (IBO) presents a robust, scalable, and safe platform for direct and durable electrical interfacing with implantable bioelectronics.
    • IBO technology facilitates on-demand ohmic connections, supporting advanced functionalities like chronic diagnostics, therapeutics, and device maintenance.
    • This innovation addresses key limitations in current bioelectronic interfaces, paving the way for more effective and long-lasting implantable devices.