Sonoenzymatically Triggered Cascading Degradation of Bioresorbable Materials for On-Demand Transient Triboelectric...

Bioresorbable materials provide temporary biomedical support but often generate wear debris during degradation, leading to immune responses and long-term complications. Here, we present a sonoenzymatic activation (SEA) materials strategy for on-demand, cascading in vivo degradation of bioresorbable systems. By coupling ultrasound-triggered mechanical disintegration with enzyme-catalyzed molecular degradation, we design a bioresorbable composite embedding enzyme-encapsulated, biocompatible metal-organic frameworks (BCEM). Ultrasound-induced cavitation enables temporally controlled enzyme release, which cleaves ester bonds in the polycaprolactone matrix. In vivo, BCEM undergoes rapid mechanical fragmentation within 15 min under medically relevant ultrasound (20 kHz, 1.0 W cm^{- 2}), followed by enzyme-assisted boosted degradation that reduces the persistence of residues over the 14-day observation period. This SEA strategy establishes a general materials platform for bioresorbable implants with programmable lifetimes and non-invasive elimination.