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In Vitro Canine Neutrophil Extracellular Trap Formation: Dynamic and Quantitative Analysis by Fluorescence Microscopy
Published on: August 24, 2018
Neutrophilic inflammatory enteropathy in 27 dogs: a retrospective descriptive study
Kevin Murtagh1, Pamela Kelly2, Robert Shiel3
1Department of Veterinary Small Animal Clinical Studies, University College Dublin, Dublin, Ireland.
Journal of Veterinary Internal Medicine
|July 8, 2026
Summary
Neutrophilic inflammatory enteropathy (NIE) in dogs is linked to poor survival outcomes. Peripheral neutrophilia may indicate a worse prognosis for dogs with this condition.
Area of Science:
- Veterinary Medicine
- Gastroenterology
- Canine Health
Background:
- Chronic inflammatory enteropathy (CIE) is prevalent in dogs.
- Neutrophilic inflammatory enteropathy (NIE) is an underreported subtype of CIE.
- NIE presents diagnostic and therapeutic challenges.
Purpose of the Study:
- To characterize the clinical presentation, diagnostics, treatment, and survival of dogs with NIE.
- To evaluate factors influencing prognosis in canine NIE.
- To provide insights into the etiology and management of NIE.
Main Methods:
- Retrospective study of 27 client-owned dogs diagnosed with NIE.
- Histological confirmation and WSAVA guideline-based grading (minor/major inflammation).
- Analysis of clinical signs, clinicopathological data, and survival times.
Main Results:
- Common signs included diarrhea, vomiting, and weight loss.
- Clinicopathological findings revealed hypoalbuminemia, hypoglobulinemia, and hypocobalaminemia.
- Overall survival to discharge was 89%; peripheral neutrophilia correlated with increased mortality risk.
Conclusions:
- NIE in dogs may be associated with a guarded prognosis.
- Peripheral neutrophilia is a potential indicator of poorer outcomes in canine NIE.
- Further research is needed to elucidate NIE's specific mechanisms and optimal treatments.
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