Related Experiment Video
Updated: Jul 10, 2026

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose
Published on: October 14, 2015
Role of Genetics in Gynecologic Malignancies
Corbyn M Nchako1, Kara C Long1, Ying L Liu2
1Department of Surgery, Gynecology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
None:
Advances in cancer genomics have transformed the prevention, classification, and management of gynecologic malignancies. Germline and somatic genetic alterations now inform hereditary cancer risk assessment, molecular tumor classification, and selection of targeted and immune-based therapies. Syndromes such as BRCA-associated hereditary breast and ovarian cancer and Lynch syndrome guide surveillance, cascade testing, and risk-reducing surgery. Molecular frameworks, including The Cancer Genome Atlas classification in endometrial cancer, refine prognosis and treatment intensity. Biomarker-driven therapies-such as poly (ADP-ribose) polymerase inhibitors, immune checkpoint inhibitors, and HER2-directed agents-have become integral across disease stages.
More Related Videos
10:27Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
09:08Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
Published on: January 12, 2020
Related Concept Videos
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Loss of Tumor Suppressor Gene Functions
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Loss of Tumor Suppressor Gene Functions
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Cancer Prevention
Some...
Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...