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Related Experiment Video

Updated: Jul 10, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

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Complementary Functional Gradient and SFC Analyses Reveal Network Abnormalities in Adolescent Depression Subtypes.

Chengyang Zeng¹, Zhigang Wu², Rui Yang¹

¹Guangyuan Mental Health Centre, Guangyuan, Sichuan, China.

Behavioural Brain Research

|July 8, 2026

Summary

This summary is machine-generated.

Adolescent major depressive disorder (MDD) with non-suicidal self-injury (NSSI) shows distinct brain functional organization and connectivity differences compared to MDD without NSSI. These findings highlight unique neurobiological pathways in adolescent depression with NSSI.

Keywords:

Adolescent Depression Functional Gradient Stepwise Functional Connectivity Subtype-specific Abnormalities

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Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

Area of Science:

Neuroscience
Developmental Psychology
Psychiatry

Background:

Adolescent major depressive disorder (MDD) is a critical neurodevelopmental disorder.
Non-suicidal self-injury (NSSI) frequently co-occurs with adolescent MDD, indicating affective dysregulation.
Previous research identified functional abnormalities in adolescent MDD, but macroscale organization and network propagation differences in MDD with NSSI remain unclear.

Purpose of the Study:

To investigate differences in macroscale functional organization and stepwise network propagation between adolescents with MDD with NSSI (MDD-NSSI), MDD without NSSI (MDD-noNSSI), and healthy controls (HC).
To utilize functional gradient (FG) analysis and stepwise functional connectivity (SFC) to explore these differences.

Main Methods:

Resting-state fMRI data from 135 adolescents (HC, MDD-NSSI, MDD-noNSSI) were analyzed using Schaefer-400 parcellation.
Functional gradients (G1, G2) were compared between groups using Welch's t-tests with BH-FDR correction.
Weighted SFC was performed using an sgACC/BA25 seed, with propagation maps computed from step 1 to 7 and compared between groups.

Main Results:

FG analysis revealed distinct gradient profiles: G1 differences were prominent in MDD-noNSSI vs HC and MDD-NSSI vs MDD-noNSSI. G2 showed extensive differences in MDD-NSSI vs HC and MDD-NSSI vs MDD-noNSSI.
SFC analysis indicated HC-relative propagation abnormalities in limbic and orbitofrontal regions for both MDD groups.
MDD-NSSI exhibited broader limbic involvement and somatomotor reductions compared to HC, while MDD-noNSSI showed a more focal temporal pole pattern.

Conclusions:

FG analysis supports distinct gradient-related profiles for adolescent MDD with and without NSSI.
SFC findings suggest broader limbic-cortical propagation abnormalities in MDD-NSSI from the sgACC/BA25 seed.
MDD-noNSSI is associated with G1-related displacement, while MDD-NSSI is linked to G2 redistribution and altered limbic-cortical connectivity.