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Updated: Jul 10, 2026

Isolation of Cells with Morphological and Spatial Information from Oral Submucous Fibrosis Samples by Laser Capture Microdissection

Isolation of Cells with Morphological and Spatial Information from Oral Submucous Fibrosis Samples by Laser Capture Microdissection

Published on: August 11, 2023

Oral potentially malignant disorders (OPMDs): An overview.

Bishwa Prakash Bhattarai¹, Ashutosh Kumar Singh², Dipak Sapkota¹

¹Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.

Advances in Immunology

|July 8, 2026

Summary

Oral potentially malignant disorders (OPMDs) carry a risk of transforming into oral squamous cell carcinoma (OSCC). Early detection and risk assessment are crucial for managing OPMDs and preventing progression to OSCC.

Keywords:

Malignant transformation epidemiology pathogenesis prognosis tobacco white lesions

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Last Updated: Jul 10, 2026

Isolation of Cells with Morphological and Spatial Information from Oral Submucous Fibrosis Samples by Laser Capture Microdissection

Isolation of Cells with Morphological and Spatial Information from Oral Submucous Fibrosis Samples by Laser Capture Microdissection

Published on: August 11, 2023

Area of Science:

Oral pathology
Oncology
Dental medicine

Background:

Oral potentially malignant disorders (OPMDs) are lesions with a risk of progressing to oral squamous cell carcinoma (OSCC).
OPMDs commonly manifest as white or red oral lesions, with oral leukoplakia being prevalent globally (4.47%).
Malignant transformation of OPMDs to OSCC occurs in approximately 7.9% of cases, with varying risks among subtypes.

Purpose of the Study:

To provide a comprehensive overview of OPMDs.
To discuss epidemiological data, etiological factors, and molecular pathogenesis.
To review diagnostic methods, treatments, and prognostic factors for oral leukoplakia.

Main Methods:

Literature review and synthesis of existing data on OPMDs.
Epidemiological analysis of OPMD prevalence and malignant transformation rates.
Discussion of diagnostic tools and treatment modalities.

Main Results:

OPMDs have a global prevalence of 4.47%, with malignant transformation rates varying significantly by subtype.
Proliferative verrucous leukoplakia (49.5%), oral erythroplakia (33.1%), and oral leukoplakia (9.5%) show the highest transformation risks.
Oral epithelial dysplasia (OED) grade correlates with malignant transformation risk, but accurate risk prediction tools are lacking.

Conclusions:

Effective management of OPMDs requires understanding their epidemiology, risk factors, and progression.
Further research is needed to develop tools for accurately identifying high-risk OPMDs.
This chapter serves as a foundational resource for understanding and managing oral leukoplakia.