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Updated: Jul 10, 2026
![Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F51444.jpg&w=3840&q=50)
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions
Published on: March 20, 2014
Ti-Catalyzed Couplings of Halopyridines and Organozinc Reagents
Jin-Long Zhao1, Jing-Yan Kong1, Xiao-Di Ma1
1College of Chemistry, Beijing Normal University, Beijing 100875, China.
Abstract:
Traditional transition metal-catalyzed coupling of 2-haloaryl metal reagents with halopyridines often results in undesirable side reactions, including further coupling of C-X bonds in 2-(2-haloaryl)pyridines or reactions involving arynes generated from 2-haloaryl metal reagents. Similarly, the coupling of alkyl metal reagents also faces the challenge of branched/linear isomerization. We describe the first titanium-catalyzed couplings of aryl/alkyl zinc reagents with halopyridines, effectively addressing these limitations and providing a versatile synthetic route to challenging pyridine derivatives.
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