Related Experiment Video
Updated: Jul 10, 2026

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
Published on: May 26, 2023
Dynamic LVOT Obstruction After Mitral Valve Repair in HCM: Treatment With a Cardiac Myosin Inhibitor
El-Moatasem Gabr1, Aravinthan Vignarajah1, Gautam Shah2
1Department of Medicine, Cleveland Clinic Fairview Hospital, Cleveland, Ohio, USA.
Mavacamten effectively treats dynamic left ventricular outflow tract obstruction (LVOTO) after mitral valve repair in hypertrophic cardiomyopathy patients. This myosin inhibitor shows promise for post-surgical LVOTO, even with altered heart geometry.
Area of Science:
- Cardiology
- Cardiac Surgery
- Pharmacology
Background:
- Mitral valve repair (MVr) can cause left ventricular outflow tract (LVOT) obstruction in hypertrophic cardiomyopathy (HCM) patients.
- Cardiac myosin inhibitors are recommended for obstructive HCM, but their use post-MVr is unclear.
Related Concept Videos
Cardiomyopathy V: Interprofessional Care
Mitral Stenosis III: Medical Management
Mitral Regurgitation III: Medical Management
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Mitral Stenosis IV: Nursing Management
Cardiomyopathy VII: Pre and Post Operative Nursing Management

