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Related Concept Videos

Spasmolytic Agents: Chemical Classification01:29

Spasmolytic Agents: Chemical Classification

Spasmolytic agents are drugs used to alleviate muscle spasms and spasticity. They can be categorized into different chemical groups based on their mechanisms of action. Centrally acting spasmolytics primarily affect the spinal cord, while others directly target skeletal muscle cells.
A major class of centrally acting spasmolytics is the α2-agonist, such as tizanidine. These drugs bind to α2-adrenoceptors, inhibiting the release of the excitatory neurotransmitter glutamate. They also promote...
Alterations in Muscle Tone ll01:12

Alterations in Muscle Tone ll

Alterations in muscle tone are common manifestations of neurological disorders and reflect dysfunction within different nervous system regions. Spasticity, paratonia, and dystonia represent distinct forms of hypertonia, each with unique mechanisms, clinical features, and diagnostic importance.CharacteristicsSpasticity happens from upper motor neuron lesions and is characterized by velocity-dependent resistance to passive movement. Clinical features include:Exaggerated deep tendon reflexesClonus...
Classification of Skeletal Muscle Relaxants01:28

Classification of Skeletal Muscle Relaxants

Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx as...

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Is Spasticity a Syndrome? A Historical Perspective on Spasticity Definitions and Descriptions.

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Factors Influencing the Selection of Botulinum Toxin Preparations for the Management of Spasticity.

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Related Experiment Video

Updated: Jul 12, 2026

Repeated Transcranial Magnetic Stimulation Combined with Action Observation Training in Children with Spastic Cerebral Palsy
07:20

Repeated Transcranial Magnetic Stimulation Combined with Action Observation Training in Children with Spastic Cerebral Palsy

Published on: August 9, 2024

Redefining Spasticity: The Spasticity X Working Group Consensus Statement.

Gerard Francisco1,2, Anand Pandyan3, Sheng Li1,2

  • 1Department of Physical Medicine and Rehabilitation (PM&R), McGovern Medical School, University of Texas Health Science Center-Houston (UTHealth), Houston, TX, USA.

American Journal of Physical Medicine & Rehabilitation
|July 9, 2026
PubMed
Summary

A new consensus definition for spasticity was developed by experts to improve clinical understanding and management. This definition clarifies spasticity as disordered sensorimotor control involving involuntary muscle overactivity during passive stretch.

Keywords:
Central Nervous SystemDefinitionModified DelphiNosologySpastic paresisSpasticityStroke

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Isokinetic Robotic Device to Improve Test-Retest and Inter-Rater Reliability for Stretch Reflex Measurements in Stroke Patients with Spasticity
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Isokinetic Robotic Device to Improve Test-Retest and Inter-Rater Reliability for Stretch Reflex Measurements in Stroke Patients with Spasticity

Published on: June 12, 2019

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Last Updated: Jul 12, 2026

Repeated Transcranial Magnetic Stimulation Combined with Action Observation Training in Children with Spastic Cerebral Palsy
07:20

Repeated Transcranial Magnetic Stimulation Combined with Action Observation Training in Children with Spastic Cerebral Palsy

Published on: August 9, 2024

Isokinetic Robotic Device to Improve Test-Retest and Inter-Rater Reliability for Stretch Reflex Measurements in Stroke Patients with Spasticity
08:40

Isokinetic Robotic Device to Improve Test-Retest and Inter-Rater Reliability for Stretch Reflex Measurements in Stroke Patients with Spasticity

Published on: June 12, 2019

Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Clinical Neuroscience

Background:

  • Existing definitions of spasticity are inconsistent and variably interpreted.
  • Evolving mechanistic understanding necessitates a clinically relevant consensus definition.
  • Current definitions lack sufficient clinical practice relevance.

Purpose of the Study:

  • To develop a concise and clinically applicable consensus definition of spasticity.
  • To reflect current understanding and support consistent assessment and management of spasticity.
  • To improve conceptual clarity and facilitate communication regarding spasticity.

Main Methods:

  • International expert panel utilizing a modified Delphi process.
  • Review of existing definitions and pre-meeting surveys.
  • Iterative refinement of draft definitions through successive rounds of voting to achieve consensus.

Main Results:

  • Key components identified: disordered sensorimotor control, central nervous system involvement, velocity- and length-dependent resistance to passive stretch.
  • Consensus definition: "A disorder of sensorimotor control resulting from upper motor neuron disease. It is characterized by velocity- and length-dependent involuntary muscle overactivity, which is intermittent or sustained, during passive stretch."
  • The new definition integrates contemporary mechanistic concepts with clinical applicability.

Conclusions:

  • The developed consensus definition enhances conceptual clarity for spasticity.
  • Improved clarity is intended to promote consistency in diagnosis, measurement, and treatment of spasticity.
  • This definition supports better communication among healthcare professionals and researchers.