Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Local Anesthetics: Clinical Application as Spinal Anesthesia

Local Anesthetics: Clinical Application as Spinal Anesthesia

Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...

Drug Delivery: Parenteral Route

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

Acute Pyelonephritis II: Diagnostic Studies and Management

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Distal femoral replacement using a hinged construct with postoperative posterior dislocation: a case series.

The Knee·2026

Same author

Coronal Plane Correction in Adults with Patient-Specific Rods.

Spine·2026

Same author

New Definition for Postoperative Spine Infection (PSI): From the Workgroup of the Musculoskeletal Infection Society (MSIS) and the European Bone & Joint Infection Society (EBJIS).

Spine·2025

Same author

Drain erosion into duodenum after cholecystectomy.

Trauma surgery & acute care open·2025

Same author

Assessing 10-Year Risk of Revision Surgery and Postoperative Complications Following Thoracic or Lumbar Fusion Surgery in HIV-Positive Patients.

Spine·2025

Same author

Trends in Lumbosacral-Pelvic Fixation Strategies.

International journal of spine surgery·2025

Search research articles

Related Experiment Video

Updated: Jul 12, 2026

In Vivo Mouse Model of Spinal Implant Infection

In Vivo Mouse Model of Spinal Implant Infection

Published on: June 23, 2020

An Algorithmic Approach Including Local Antibiotic Delivery for Spine Infection Treatment: Outcomes at 1 Institution.

Mellissa R Delcont¹, Anna Sater², Jonathan Layne³

¹Department of Anesthesiology, Baylor College of Medicine, Houston, TX, USA.

International Journal of Spine Surgery

|July 9, 2026

Summary

Calcium sulfate antibiotic beads, when used with a structured treatment plan, effectively treat spine infections with low systemic toxicity. Minimizing bead volume is key to preventing hypercalcemia, and patients with kidney or liver issues need careful management.

Keywords:

antibiotic beads calcium sulfate beads local antibiotic delivery spine infection surgical debridement

More Related Videos

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

Published on: October 25, 2024

Related Experiment Videos

Last Updated: Jul 12, 2026

In Vivo Mouse Model of Spinal Implant Infection

In Vivo Mouse Model of Spinal Implant Infection

Published on: June 23, 2020

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

Published on: October 25, 2024

Area of Science:

Orthopedic Surgery
Infectious Diseases
Pharmacology

Background:

Spine infection treatment often involves systemic antibiotics and debridement, but lacks standardized algorithmic approaches.
Local antibiotic delivery via dissolvable calcium sulfate carriers is underutilized in spinal infections despite success in other orthopedic sites.

Purpose of the Study:

To evaluate the efficacy and safety of institutional protocols for surgically managed spine infections using calcium sulfate antibiotic beads.
To identify risk factors for treatment failure and adverse events associated with these beads.
To analyze the microbiological characteristics of treated spine infections.

Main Methods:

Retrospective analysis of 119 patients with surgically managed spine infections (2016-2020).
Treatment included debridement, stabilization, local antibiotic beads (calcium sulfate), and systemic antibiotics.
Univariate logistic regression analyzed factors associated with treatment failure.

Main Results:

81.5% of patients achieved infection resolution; 16 experienced recurrence, and 6 died from sepsis.
Acute kidney and liver injuries were linked to treatment failure.
Calcium sulfate bead volume correlated with transient hypercalcemia, resolving without bead removal.
Polymicrobial infections were most common.

Conclusions:

Incorporating calcium sulfate antibiotic beads into an algorithmic approach successfully eradicates spine infections with minimal systemic toxicity.
Careful patient selection and limiting bead volume are crucial for mitigating adverse effects like hypercalcemia.
Patients with pre-existing renal or hepatic compromise may necessitate more intensive treatment strategies.