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Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

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Obesity, Weight Loss, and Rhinology and Allergy.

Chase Kahn¹, Christopher Roxbury¹, Mohamad R Chaaban¹

¹Department of Otolaryngology-Head and Neck Surgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.

Otolaryngologic Clinics of North America

|July 9, 2026

Summary

Obesity worsens chronic rhinosinusitis, especially nasal polyps, via inflammation. Weight loss interventions like bariatric surgery and GLP-1 agonists may reduce sinonasal disease and improve outcomes.

Keywords:

Allergic rhinitis Bariatric surgery Chronic rhinosinusitis GLP-1 receptor agonists Leptin Nasal polyps Obesity Weight loss

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Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Area of Science:

Otolaryngology
Allergy and Immunology
Metabolic Disease

Background:

Obesity is a frequent comorbidity in patients with rhinologic and allergic conditions.
Emerging evidence links obesity to increased risk and severity of chronic rhinosinusitis (CRS), particularly the nasal polyp phenotype.
Adipokine-mediated inflammation is a key mechanism connecting obesity and CRS severity.

Purpose of the Study:

To review current evidence on the relationship between obesity, weight loss, and rhinology/allergy.
To highlight clinically actionable implications for otolaryngologists managing patients with CRS and obesity.
To explore the impact of weight reduction interventions on sinonasal disease burden.

Main Methods:

Systematic review of existing literature.
Synthesis of evidence on obesity's role in CRS pathogenesis.
Analysis of weight loss strategies (bariatric surgery, pharmacologic) and their effects on sinonasal outcomes.

Main Results:

Obesity is associated with increased inflammation and severity in chronic rhinosinusitis, especially with nasal polyps.
Weight reduction interventions show potential for decreasing sinonasal disease burden.
Pharmacologic agents like glucagon-like peptide-1 receptor agonists are emerging as options for weight management and potential CRS improvement.

Conclusions:

Weight management is a crucial consideration in the treatment of chronic rhinosinusitis, particularly in obese patients.
Interventions aimed at reducing body mass may improve sinonasal disease severity and surgical outcomes.
Further research is warranted to fully elucidate the benefits of weight loss strategies in otolaryngologic practice.