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Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses
Published on: February 3, 2022
Exclusion of immune cells by vascular gates
1Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
None:
Neuroendocrine carcinomas, including small cell lung cancers, are notable for their immune desert phenotype, even with the addition of immunotherapies. While this has been attributed to absent antigen presentation, Wang and colleagues demonstrate the existence of a vascular barrier that limits T cell infiltration and physically underlies this phenotype.
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