Related Experiment Video

Updated: Jan 28, 2026

Microinjection Wound Assay and In vivo Localization of Epidermal Wound Response Reporters in Drosophila Embryos.
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Microinjection Wound Assay and In vivo Localization of Epidermal Wound Response Reporters in Drosophila Embryos.

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First Report of Response to Tarlatamab in a Patient With Histologic-Transformed SCLC From ALK-Rearranged NSCLC: Case

Kaiwen Wang1, Ceylan Altintas Taslic2, Patricia de Groot3

  • 1Division of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, Texas.

JTO Clinical and Research Reports
|January 26, 2026
PubMed

Insights

Small cell transformation is a challenge in ALK-rearranged NSCLC. Tarlatamab showed clinical benefit, including intracranial response, in a patient with transformed disease resistant to prior therapies.

Area of Science:

  • Oncology
  • Thoracic Cancers
  • Molecular Targeted Therapy

Background:

  • Small cell transformation is a known resistance mechanism to targeted therapies in non-small cell lung cancer (NSCLC) with EGFR mutations.
  • This transformation is less commonly reported in ALK-rearranged NSCLC but presents a significant unmet clinical need due to lack of standard treatments.
  • Patients with actionable oncogenic alterations progressing to small cell lung cancer (SCLC) face limited therapeutic options.
Keywords:
ALKCase reportLorlatinibSmall cell transformationTarlatamab

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